第195章 从业者良心
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重生之工艺强国第195章从业者良心方翰民并未把老梁的自责放在心上,他心里很清楚,班子里的几位副手,虽然不像分管生产的王副厂长那样,明目张胆地跟他作对,但一个个都有自己的小盘算,工作上得过且过,多一事不如少一事,遇到问题往外推,谁也不愿担责任。
方翰民把主要精力放在科研生产上,他既没有兴趣,也没有精力琢磨人,对于副手们的所作所为,他看在眼里,只要说得过去,从不跟他们计较,毕竟有一个王副厂长就够他烦了,在不违背大原则的情况下,大家相安无事,免得徒增烦恼,倒也落得个清静。
但是,方翰民也看得出来,梁副厂长这次自责确实发自内心,出于相互尊重,他安慰了几句,老梁就回自己办公室去了。
......
根据方翰民指出的探索方向,仿制药课题组对碱性拆分剂进行有效性考察,通过两三个月试验,对七八种生物碱的拆分效果做了对比,发现了两种分离效果很好的拆分剂,一种名为-马钱子碱,另一种叫-α-苯乙胺。
郭鹏等科技人员接触光学拆分技术时间不长,对这门技术的了解还停留在表面,试验完成后,他们把试验记录和检测结果呈送到方翰民面前,等待他的分析判断。
从试验结果和检测数据上看,马钱子碱和苯乙胺的拆分效果明显好于酸类拆分剂,而且相互之间难分伯仲,毫无疑问,这两种生物碱成了最佳候选拆分剂。
但是,在确定最终的拆分工艺之前,必须二选一,在这两种拆分剂中选出最合理的一种,作为工艺定型原料。
在拆分效果相同的情况下,需要考虑其他因素的影响,比如拆分剂的价格、是否容易购买、本身的毒性、和目标产物是否容易分离,以及回收易难程度,等等,只有对各方面情况进行仔细分析,并经过综合对比之后,才能确定最终采用哪种拆分剂。
马钱子碱最早从植物中提取,但在一九五四年就在国外被人工合成出来,国内相关行业的科技人员也掌握了这种物质的合成技术,到了八十年代末九十年代初,国内市场已经不缺这种产品。苯乙胺是人体大脑中分泌的一种化合物,不过,市售的苯乙胺都来自于人工合成。
就价格而言,因为生产两种拆分剂的原料路线和工艺流程差别很大,马钱子碱的生产成本相对较低,而苯乙胺的成本较高,导致马钱子碱的市售价格比苯乙胺低百分之二十左右。
当然,两种拆分剂均可在市场上方便购买。
在光学拆分工艺中,拆分剂跟仿制药物的有效成分或反式异构体形成外消旋化合物,因为马钱子碱跟药物有效成分或反式异构体都是固体结晶颗粒,两者的分离很难达到理想状态,比较而言,苯乙胺跟药物有效成分反或式异构体的分离更为彻底。
根据两种化合物的理化性质可以做出判断,马钱子碱无论跟药物有效成分还是反式异构体分离后,回收比较方便;而苯乙胺作为一种高沸点液体物质,回收比较麻烦。
听了方翰民的分析对比,课题组的科技人员一致认为,应该选择马钱
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